Poison!
Poison Joke
|
|
"What'll ya have?" he asked.
"Oh, I don't know. The same as you I suppose," she replied.
So the husband ordered a couple of Jack Daniel's and threw his down in one go. His wife watched him, then took a sip from her glass and immediately spat it out.
"Yuck, it's nasty poison!" she spluttered. "I don't know how you can drink this stuff!"
"Well, there you go," cried the husband. "And you think I'm out enjoying myself every night!"
Poison
In the context of biology, poisons are substances that can cause injury, illness, or death to organisms, usually by chemical reaction or other activity on the molecular scale, when a sufficient quantity is absorbed by an organism. Paracelsus, the father of toxicology states-- "Everything is poison, there is poison in everything. Only the dose makes a thing not a poison".In medicine (particularly veterinary) and in zoology, a poison is often distinguished from a venom. Venoms are usually defined as biologic toxins that are injected to cause their effect, while poisons are generally defined as substances which are absorbed through epithelial linings such as the skin or gut.
Poison Terminology
Some poisons are also toxins, usually referring to naturally produced substances, such as the bacterial proteins that cause tetanus and botulism. A distinction between the two terms is not always observed, even among scientists.Animal toxins that are delivered subcutaneously (e.g. by sting or bite) are also called venom. In normal usage, a poisonous organism is one that is harmful to consume, but a venomous organism uses poison to defend itself while still alive. A single organism can be both venomous and poisonous.
The derivative forms "toxic" and "poisonous" are synonymous.
Within chemistry and physics, a poison is a substance that obstructs or inhibits a reaction, for example by binding to a catalyst.
Poison Lay use
The phrase "poison" is often used colloquially to describe any harmful substance:Carcinogens, such as asbestos, benzene, carbon tetrachloride, dioxin, tobacco and some artificial sweeteners. Mutagens, such as ultraviolet rays (long-term exposure may cause skincancer) and other ionizing radiation that may cause radiation sickness and cancer). Teratogens, such as thalidomide. Pollutants can be poisonous, or they can be non-poisonous but harmful in other ways.
Poison Warning symbols
Poisons have been known to be symbolized by the skull and crossbones, indicating lethal potential. This is the UN standard symbol, used in the European Union. However, it can be considered a liability for marketing. In the United States, other symbols such as Mr. Yuk are replacing the skull and crossbones. Proponents of the Mr. Yuk argue that the skull-and-crossbones symbols attracts children because of its association to Pirates, and assert that Mr. Yuk does not.Chemicals with non-lethal hazards, such as corrosivity, mild toxicity and harmfulness, may be informally referred to as "poisons", but are not usually marked with the skull-and-crossbones symbol. To contrast, harmful, environmentally hazardous and irritant. The UN standard symbol for harmful and irritant substances is an 'X' on an orange background. This is applied to materials with non-lethal hazards as well as to potentially lethal materials.
Uses of poison
The uses of poisons specifically because of their toxicity is limited. Applications have been mainly for controlling pests and weeds, and for preserving building materials and food stuffs. Where possible, specific agents which are less poisonous to humans have come to be preferred, but exceptions such as phosphine continue in use.Throughout human history, intentional application of poison has been used as a method of assassination, Murder, suicide and execution. As a method of execution, poison has been ingested, as the ancient Athenians did (see Socrates), inhaled, as with carbon monoxide or hydrogen cyanide (see gas chamber), or injected (see lethal injection). Many languages describe lethal injection with their corresponding words for "poison shot".
Poisonous materials are often used for their chemical or physical properties other than being poisonous. The most effective, easiest, safest, or cheapest option for use in a chemical synthesis may be a poisonous material. Particularly in experimental laboratory syntheses a specific reactivity is used, despite the toxicity of the reagent. Chromic acid is an example of such a "simple to use" reagent. Many technical applications call for some specific physical properties; a toxic substance may possess these properties and therefore be superior. Reactivity, in particular, is important. Hydrogen fluoride, for example, is poisonous and extremely corrosive. However, it has a high affinity for silicon, which is exploited by using HF to etch glass or to manufacture silicon semiconductor chips.
Biological poisoning
Acute poisoning is exposure to a poison on one occasion or during a short period of time. Symptoms develop in close relation to the exposure.Chronic poisoning is long-term repeated or continuous exposure to a poison where symptoms do not occur immediately or after each exposure. The patient gradually becomes ill, or becomes ill after a long latent period. Chronic poisoning most commonly occurs following exposure to poisons that bioaccumulate such as mercury and lead.
Contact or absorption of poisons can cause rapid death or impairment. Agents that act on the nervous system can paralyze in seconds or less, and include both biologically derived neurotoxins and so-called nerve gases, which may be synthesized for warfare or industry.
Inhaled or ingested cyanide as used as method of execution on US gas chambers almost instantly starves the body of energy by inhibiting the enzymes in mitochondria that make ATP. Intravenous injection of an unnaturally high concentration of potassium chloride, such as in the execution of prisoners in parts of the United States, quickly stops the heart by eliminating the cell potential necessary for muscle contraction.
Most (but not all) pesticides are created to act as poisons to target organisms, although acute or less observable chronic poisoning can also occur in non-target organism, including the humans who apply the pesticides and other beneficial organisms.
Many substances regarded as poisons are toxic only indirectly. An example is "wood alcohol" or methanol, which is not poisonous itself, but is chemically converted to toxic formaldehyde and formic acid in the liver. Many drug molecules are made toxic in the liver, and the genetic variability of certain liver enzymes makes the toxicity of many compounds differ between individuals.
The study of the symptoms, mechanisms, treatment and diagnosis of biological poisoning is known as toxicology.
Exposure to radioactive substances can produce radiation poisoning, an unrelated phenomenon.
Poisoning in humans
Poison and Children
Poisoning is the fourth most common cause of accidental deaths in children.Children less than 5 years of age, as well as adolescents, are prone to poisoning.
Accidental ingestions are most common in children less than 5 years old.
90% of all poisonings occur at home, the most common sites being the kitchen and the bathroom.
Unintentional poisonings occur most frequently when routines are disrupted, for example moving and vacations.
Child safety caps have helped decrease the number of poisonings; however, they are not 100% effective and should not give a false sense of security. All potential poisons should be properly labeled, stored out of reach of children, and locked.
Adolescent ingestions are more typically a result of suicidal attempts or experimentation with illicit drugs.
Parents should receive anticipatory guidance regarding poisonings and should have the number to reach their local poison control center available, in the USA the phone number is 1-800-222-1222. Poison control centers are free, 24 hours, and confidential.
Poisoning management
Poison Control Centers (In the US reachable at 1-800-222-1222 at all hours) provide immediate, free, and expert treatment advice and assistance over the telephone in case of suspected exposure to poisons or toxic substances.Poison General first aid
If the poison is an inhalant, remove the patient from the area and to fresh air. If the poisoning is affecting the skin, remove the clothing and wash the skin thoroughly unless a dry powder is the cause of the poisoning.If the poison is in the eye, flush the eye thoroughly for at least 15 minutes. Following ingestion, ensure the person remains calm, do not induce vomiting, small fluids are recommended for corrosive substances (e.g. household cleaners). Following these measures a poison control center can be contacted for advice on what to do next.
Poison Initial medical management
Initial management for all poisonings includes ensuring adequate cardiopulmonary function and providing treatment for any symptoms such as seizures, shock, and pain.Poison Decontamination
The goal of gastric decontamination is to prevent absorption of the toxin. This may be achieved using activated charcoal, whole bowel irrigation, or nasogastric aspiration. Gastric lavage, cathartics, emesis, or Ipecac are no longer routinely recommended.Activated charcoal is the treatment of choice to prevent absorption of the poison. It is usually administered when the patient is in the emergency room. However, charcoal is ineffective against metals, Na, K, alcohols, glycols, acids, and alkalis.
Whole bowel irrigation cleanses the bowel, this is achieved by giving the patient large amounts of a polyethylene glycol solution. The osmotically balanced polyethylene glycol solution is not absorbed into the body, having the effect of flushing out the entire gastrointestinal tract. Its major uses are following ingestion of sustained release drugs, toxins that are not absorbed by activated charcoal (i.e. lithium, iron), and for the removal of ingested packets of drugs (body packing/smuggling).
Nasogastric aspiration involves the placement of a tube via the nose down into the stomach, the stomach contents are then removed via suction. This procedure is mainly used for liquid ingestions where activated charcoal is ineffective, i.e. ethylene glycol.
Gastric lavage, commonly known as a stomach pump, is the insertion of a tube through the mouth down into the stomach, followed by administration of water or saline down the tube, the liquid is then removed again, having the overall effect of removing the contents of the stomach. Lavage has been used for many years as an initial treatment for poisoned patients, however, a recent review of the procedure for poison ingestions suggested lavage should no longer be employed routinely, if ever, in the management of poisoned patients. It is still sometimes performed if it can be performed within 1 h of ingestion and the dose is potentially life threatening.
Poison Emesis
Cathartics were postulated to decrease absorption by increasing the expulsion of the poison from the gastrointestinal tract. There are two types of cathartics used in poisoned patients; saline cathartics (sodium sulfate, magnesium citrate, magnesium sulfate) and saccharide cathartics (sorbitol). They do not appear to improve patient outcome and are no longer recommended.Poison Antidotes
Some poisons have specific antidotes:Poison and Drug Antidote
paracetamol acetylcysteineVitamin K anticoagulants vitamin K
opioids naloxone
iron (and other heavy metals) deferoxamine
benzodiazepines flumazenil
ethylene glycol ethanol or fomepizole
methanol ethanol or fomepizole
cyanide amyl nitrite, sodium nitrite & sodium thiosulphate
Poison Enhanced excretion
In some situations elimination of the poison can be enhanced using diuresis, hemodialysis, hemoperfusion, peritoneal dialysis, or exchange transfusion.Poison Further treatment
In the majority of poisonings the mainstay of management is providing supportive care for the patient, i.e. treating the symptoms rather than the poison.Types of poisons
The majority of this section is sorted by ICD-10 code, which classifies poisons based upon the nature of the poison itself. However, it is also possible to classify poisons based upon the effect the poison has (for example, "Metabolic poisons" such as Antimycin, Malonate, and 2,4-Dinitrophenol act by adversely disrupting the normal metabolism of an organism.)
(T36-T50) Poisoning by drugs, medicaments and biological substances
(T36.) Poisoning by systemic antibiotics
(T37.) Poisoning by other systemic anti-infectives and antiparasitics
(T38.) Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
(T39.) Poisoning by nonopiod analgesics, antipyretics and antirheumatics
(T40.) Poisoning by narcotics and psychodysleptics (hallucinogens)
(T41.) Poisoning by anaesthetics and therapeutic gases
(T42.) Poisoning by antiepileptic, sedative-hypnotic and antiparkinsonism drugs
(T43.) Poisoning by psychotropic drugs, not elsewhere classified
