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Xanax!

Xanax

Xanax is a short-acting drug in the benzodiazepine class used to treat anxiety disorders and as an adjunctive treatment for depression.

Xanax was invented by Pfizer and is marketed under the trade name Xanax. Its patent expired in September 1993.

Xanax Pharmacology

Xanax is a triazolobenzodiazepine, that is, a benzodiazepine with a triazolo-ring attached to its structure. Xanax binds to the GABAA subtype of the GABA receptor, increasing inhibitory effects of GABA within the central nervous system. The binding site for benzodiazepines is distinct from the binding site for barbiturates and GABA on the GABA receptor.

Unlike other benzodiazepines, Xanax may also have some antidepressant activity, although clinical evidence of this is lacking.

Xanax Pharmacokinetics

The mechanism of action is not fully understood; However, Xanax is readily absorbed from the gastrointestinal tract. The peak plasma concentration is achieved in 1-2 hours. Most of the drug is bound to plasma protein, mainly albumin. Xanax is hydroxylated in the liver to a-hydroxy Xanax, which is also pharmacologically active. This and other metabolites are later excreted in urine as glucuronides. Some of the drug is also excreted in unchanged form.



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